The series was celebrated with numerous other PlayStation franchises in the PlayStation 5 game Astro's Playroom. In June 2021, game developer and former IGN PlayStation editor Colin Moriarty revealed his contacts at Insomniac had pitched a sequel to Sony, but it was rejected due to the number of post-apocalyptic games in development, including The Last of Us and Days Gone. In August 2018, Insomniac's community director James Stevenson called chances of a Resistance 4 "a longshot" revealing that neither the developer, nor Sony who owns the IP, were talking about a sequel. All online features of the Resistance games have been discontinued in March 2014. Insomniac CEO Ted Price said that Insomniac "won't be making any more Resistance games".
The game follows the story of Tom Riley, a firefighter who sets out to find his family while fighting the Chimera, who have now taken over the American east coast.Īccording to Resistance 3 creative director Marcus Smith, the studio has a number of franchises it wants to pursue and that Resistance is not one of them. RNase antibiotic adjuvant antimicrobial peptides antimicrobial resistance gram-negative bacteria.Resistance: Burning Skies was released on the PlayStation Vita May 29, 2012. The results advance the potential applicability of RNase-based drugs as antibiotic adjuvants.
Subsequently, using an in vitro experimental evolution assay, by exposure of a bacterial culture to colistin at incremental doses, we demonstrated the ability of the RNase 3/1 construct to reduce the emergence of bacterial antimicrobial resistance.
Positive synergism was observed between colistin and the RNase 3/1 hybrid protein. Synergy assays were performed in combination with colistin, a standard antimicrobial peptide used as an antibiotic to treat severe infections. Next, we have explored the ability of this hybrid RNase to target the development of bacterial resistance on an Acinetobacter baumannii cell culture. Based on structure-functional studies we have designed an RNase 3/1 hybrid construct that combines the high catalytic activity of RNase 1 with RNase 3 bactericidal properties. Its enhanced ability to disrupt the bacterial cell wall has evolved in detriment of its catalytic activity. Among the eight human canonical RNases, RNase 3 stands out as the most cationic and effective bactericidal protein against Gram-negative species. Human antimicrobial RNases belonging to the vertebrate specific RNase A superfamily participate in the maintenance of tissue and body fluid sterility. They exert a rapid and multifaceted action that reduces the development of bacterial adaptation mechanisms. Antimicrobial proteins and peptides (AMPs) are the key players in host innate immunity. The emergence of bacterial resistance to the most commonly used antibiotics encourages the design of novel antimicrobial drugs.
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